Devalia JL, Rusznak C, Wang J, Khair OA, Abdelaziz MM,
Calderon MA, Davies RJ.
Department of Respiratory Medicine and Allergy, St.
Bartholomew's Hospital, London, UK.
Epidemiological evidence suggests that an increase in
liquid petroleum derived pollutants is associated with
exacerbation of allergic airway disease, and that the
effects of pollution may occur 1-2 days later.
Laboratory based studies have demonstrated that the
pollutants responsible for the adverse effects on
respiratory health include nitrogen dioxide (NO2),
sulphur dioxide (SO2), ozone (O3) and respirable
particulates (PM10). More recently, studies of asthmatic
individuals exposed to O3, NO2 and a combination of NO2
and SO2 have indicated that these agents increase the
airway responsiveness of these individuals to inhaled
allergen, and that this effect may be maximal 24 h after
exposure to the pollutants. Studies investigating the
putative mechanisms underlying the effects of these
pollutants suggest that exposure to these agents may
lead to perturbation of the airway epithelium and
release of pro-inflammatory mediators from the
epithelial cells, which then influence the activity of
inflammatory cells, such as eosinophils.
PMID: 8711769 [PubMed - indexed for MEDLINE]