Hypertrophic cranial pachymeningitis due to Aspergillus flavus-Japan
Murai H, Kira J, Kobayashi T, Goto I, Inoue H, Hasuo K.
Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
A 59-year-old woman suffered from occipital headache and bilateral cranial nerve VII, VIII, IX, X, XI and right XII deficit after developing otitis media. Magnetic resonance imaging (MRI) showed a thickening of the dura mater which was enhanced by gadolinium-DTPA (Gd). Aspergillus flavus was identified from the culture of otorrhea. She was treated with miconazole, flucytosin and fluconazole, which resulted in an improvement of the clinical symptoms and a thinning of the Gd-enhanced lesions on MRI. This is the first case of hypertrophic cranial pachymeningitis caused by Asp. flavus infection.
PMID: 1327616 [PubMed - indexed for MEDLINE]