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J Epidemiol Community Health. 2005
Aug;59(8):685-93.
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Increased resting heart rate with
pollutants in a population based study
Ruidavets JB,
Cassadou S,
Cournot M,
Bataille V,
Meybeck M,
Ferrieres J.
INSERM U558, Faculte de Medecine, 37 allees Jules
Guesde, 31073 Toulouse cedex, France. jean-bernard.ruidavets@cict.fr
BACKGROUND: Air pollution is associated with
cardiovascular mortality. Changes in the autonomic
nervous system may contribute to cardiac arrhythmias
and cardiovascular mortality. This study
investigated the relations between air pollutant
concentrations of sulphur dioxide (SO(2)), ozone
(O(3)), nitric dioxide (NO(2)), and resting heart
rate (RHR) in a population based study. METHODS: A
sample of 863 middle aged men and women, living in
Toulouse (MONICA centre) area, was randomly
recruited. A cross sectional survey on
cardiovascular risk factors was carried. RHR was
measured twice in a sitting position after a five
minute rest. Multivariate analyses with quintiles of
RHR were performed using polytomous logistic
regression. Models were adjusted for temperature,
season, relative humidity, sex, physical activity,
blood pressure, C reactive protein, and
cardiovascular drugs. RESULTS: For NO(2), the OR
(odds ratio) (95% CI) associated with an increase of
5 microg/m(3) in the current day of medical
examination was 1.14 (1.03 to 1.25) in quintile Q5
of RHR compared with Q1, p for trend = 0.003. For
SO(2), OR was 1.16 (0.94 to 1.44) in Q5 compared
with Q1, p for trend = 0.05, and for O(3), OR was
0.96 (0.91 to 1.01) in Q5 compared with Q1, p for
trend = 0.11. No significant association was seen
when the daily mean concentration of NO(2), SO(2),
and O(3) was considered during the previous day as
well as when day lag 2 or 3 was considered. The
cumulative concentration (three consecutive days) of
O(3) is negatively associated with RHR (p for trend
= 0.02). CONCLUSION: Changes in pulse rate could
reflect cardiac rhythm changes and may be part of
the pathophysiological link between pollution and
cardiovascular mortality.
PMID: 16020647 [PubMed - indexed for MEDLINE]
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