Aflatoxin B1 and reproduction
1: Afr J Reprod Health. 1997 Sep;1(2):85-9.
Aflatoxin B1 and reproduction. II. Gametoxicity in female rats
Ibeh IN, Saxena DK.
Department of Microbiology, Faculty of Science, University of Benin,
It has been reported that aflatoxin B1 impairs the reproductive
performance of female animals. The mechanism of action of this toxin on
the reproductive system was investigated. Female Druckery Strain rats
were administered aflatoxin B1 at doses of 7.5 and 15.0 mg/kg body
weight through oral intubation for 21 days. The ovary was examined by
counting superovulated oocytes and the follicles in 6 mm thick sections.
Estradiol and progesterone blood levels were determined. The body and
whoopy organ weights of rats were recorded. There were significant
reductions in the number of oocytes and large follicles in a dose
dependent response. The blood hormone level and body and whoopy organ
weight were significantly disturbed. We propose that aflatoxin B1 is
gametotoxic and deranges hormonal balance in affected animals.