Pulmonary aspergillosis with possible
1: J Chemother. 2004 Dec;16(6):604-7.
Pulmonary aspergillosis with possible cerebral involvement in a
previously healthy pregnant woman.
Pagliano P, Attanasio V, Fusco U, Rossi M, Scarano F, Faella FS.
Department of Emergency and Infectious Diseases, D. Cotugno
Hospital, Via G. Quagliariello 54, 80131 Naples, Italy.
Invasive aspergillosis is observed mainly in
immunodepressed patients. Here we report a case of pulmonary
aspergillosis with CNS involvement in a pregnant woman without
other known causes of immunodeficiency. Case report: A 23-years
old pregnant woman underwent a caesarean because of unexplained
seizures. During the subsequent days worsening headache and a
deteriorating neurological status were reported suggesting
meningitis. Stiffness, right sided hemiparesis and cranial nerve
palsies were observed at admission. Radiological findings
revealed lesions involving the right pulmonary apex, the right
cerebellar hemisphere and the Pterygopalatina fossa.
Microbiological studies revealed large colonies of Aspergillus
fumigatus. A favorable outcome was observed after administration
of liposomal amphotericin B and 5-fluorocytosine and, at
improved conditions, when oral uptake of itraconazole was given.
The authors conclude that risk of infections sustained by fungal
opportunistic agents during pregnancy must be considered.
Sequential antifungal administration may be an efficient therapy
able to shorten hospitalization.