Sensitivity to Quorn mycoprotein (Fusarium venenatum) in a mould allergic patient
Department of Immunology, Level 7, Derriford Hospital, Plymouth, Devon PL6 8DH, UK; firstname.lastname@example.org
Keywords: RANKL; skeletal metastases
A 27 year old female civil servant presented with five episodes of peri-orbital, tongue, and neck angio-oedema with wheeze and shortness of breath. One of these episodes occurred a few minutes after eating a Quorn burger. She had a 20 year history of perennial sneezing, rhinorrhea, and itchy throat, occurring throughout the day and night, but no cough or wheezing. While on holiday in Mauritius she was asymptomatic. Twelve years previously, she had received six months of weekly injections of alternaria, cladosporium, helminthosporium, and stempylium as immunotherapy in France. She had no pets, but had noticed mould on her bedroom and bathroom windows.
Skin prick testing and specific IgE results suggested type 1 hypersensitivities to Quorn, Alternaria alternata, Aureobasidium pullulans, cat dander, and grass pollen (table 1). Scrapings from her bathroom and bedroom windows grew heavy growths of Cladosporium sphaerospermum, Rhodotorula sp, Aureobasidium pullulans, and fewer numbers of non-sporing mould (Mycology Reference Laboratory, Bristol, UK).
Quorn mycoprotein is produced by Marlow Foods Ltd, from the fungus Fusarium venenatum. Approximately 1/140 000 consumers report adverse reactions after eating Quorn. Ten such complainants had negative skin prick tests to an aqueous extract of fresh Quorn.3 Thirty three Quorn production workers did not have high titres of IgE specific to Quorn, although six known mould allergic subjects did.3 This study suggested that the risk of sensitisation to Quorn was low, but that patients who were allergic to mould might react adversely to inhaled or ingested mycoprotein. Crossreactivity studies showed that Quorn shared multiple allergenic determinants with Aspergillus fumigatus, Cladosporium herbarum, and Alternaria alternata.3 Allergen preparations for skin prick testing and specific IgE tests are poorly standardised, and may differ in their potency as much as 200–3000 fold.4 The diversity of fungal allergens is a challenge for successful immunotherapy.
A reduction in occupational exposure to fungi may be achieved using helmets with filtered air (which may remove up to 98% of spores), improving ventilation, and controlling humidity. Fungi in dwellings generally have no specialised spore liberation mechanisms and largely depend on disturbance. Spore wall structure determines whether allergens are already available on the surface, and whether the spores can remain airborne.