1: Med Mycol. 2004 Aug;42(4):379-83.
Ricci G, Mota FT, Wakamatsu A, Serafim RC, Borra RC, Franco M.
Department of Pathology, Federal University of Sao Paulo (UNIFESP-EPM),
Sao Paulo, Brazil.
Paracoccidioidomycosis (PCM) is a severe disease caused by the dimorphic
fungus Paracoccidioides brasiliensis, which is characterized by
granulomatous pulmonary and systemic lesions, affecting mainly men
between 20 and 60 years of age. Reports of PCM disease in animals are
rare, but the disease has been described in armadillos. On the other
hand, PCM infection of domestic and wild animals detected by serological
or cutaneous tests in the absence of apparent disease has been
frequently reported. We present here the case of a female adult Doberman
that developed cervical lymphadenomegaly. Histopathological examination
of a cervical biopsy specimen revealed active PCM, with an epithelioid,
granulomatous inflammation containing numerous yeast-like, multiple
budding fungal forms. The diagnosis of PCM was confirmed by
immunohistochemistry using a specific antibody anti-gp43 and by nested
PCR using primers for the amplification of the gp43 gene region. This is
the first report of PCM disease occurring in a dog, an animal that has
been shown to play an important role in the natural history of North