Cognitive impairment associated with toxigenic fungal
1: Appl Neuropsychol. 2004;11(2):65-74.
Cognitive impairment associated with toxigenic fungal exposure: a
replication and extension of previous findings
Gordon WA, Cantor JB, Johanning E, Charatz HJ, Ashman TA, Breeze JL,
Haddad L, Abramowitz S.
In this study, neuropsychological data and symptom reports from 31
individuals exposed to toxic mold were examined. Most participants were
found to have reduced cognitive functioning in multiple domains, with
memory and executive functions the most commonly affected areas. Rates
of dysfunction were significantly greater than chance on more than half
of the tests. Number of cognitive impairments was found to be related to
depression, although few neuropsychological test scores were correlated
with depression. Results also indicated that symptom report of the
mold-exposed participants was not significantly different from that of
matched groups of 65 persons with mild traumatic brain injury (TBI) and
26 individuals with moderate TBI. The mold-exposed participants reported
significantly more symptoms than 47 people with no disability. This
study adds to a growing body of literature (e.g., Baldo, Ahmad, & Ruff,
2002; Gordon, Johanning, & Haddad, 1999) relating exposure to mycotoxins
to cognitive dysfunction.