Efficacy of silymarin-phospholipid complex
in reducing the
1: Poult Sci. 2004 Nov;83(11):1839-43.
Efficacy of silymarin-phospholipid complex in reducing the
toxicity of aflatoxin B1 in broiler chicks
Tedesco D, Steidler S, Galletti S, Tameni M, Sonzogni O,
Department of Veterinary Science and Technology for Food Safety,
Via Celoria, 10, 20133 Milan, Italy.
Silymarin, the standardized extract of Silybum marianum, is used
as a hepatoprotector in man, and is a potent antihepatotoxic
agent. This study focused on the effects of a
silymarin-phospholipid complex in reducing the toxic effects of
aflatoxin B1 (AFB1) in broiler chickens. Twenty-one 14-d-old
male commercial broilers were randomly allotted to 3 groups and
treated as follows: basal diet alone [Group C (Control)]; AFB1
at 0.8 mg/kg of feed [Group B1]; AFB1 at 0.8 mg/kg of feed plus
silymarin phytosome, a silymarin complexed form with
phospholipids from soy, at 600 mg/kg of BW [Group B1+Sil].
Considering the whole growth cycle, BW gain and feed intake were
lower in AFB1-treated birds with respect to controls (P < 0.05).
In the B1+Sil group, BW gain and feed intake were higher with
respect to birds receiving AFB1 alone (P < 0.05), and not
different from the control birds. Serum biochemistry showed no
difference among groups, except for a decrease of alanine amino
transferase (ALT) in chicks treated only with AFB1. Alanine
amino transferase activity in AFB1 plus silymarin phytosome
treated birds was not different from the controls. No treatment
differences were noted on liver weight. In conclusion, our
results suggest that silymarin phytosome can provide protection
against the negative effects of AFB1 on performance of broiler